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Harvard Women's Health Watch
In
Crestor is one of several statins -- drugs that reduce cholesterol in the blood by inhibiting its production in the liver. Statins lower total cholesterol, LDL (bad) cholesterol, and triglycerides; slightly raise HDL (good) cholesterol; and reduce C-reactive protein (CRP), a marker of inflammation. Crestor and other statins have already been approved to slow the progression of cardiovascular disease and to reduce elevated cholesterol in healthy people. Crestor is now approved for men ages 50 and over and women ages 60 and over who have normal LDL cholesterol but elevated CRP levels (as measured by a high-sensitivity test called hs-CRP) and one additional cardiac risk factor, such as high blood pressure, low HDL cholesterol, or smoking. The
In expanding the uses of Crestor, the agency cited evidence from JUPITER, a trial involving nearly 18,000 healthy women and men with elevated CRP levels but normal levels of LDL cholesterol. In that study, published in
In the Circulation report, a team led by researchers from Boston's Brigham and
The
Funding for the Circulation study came from several statin manufacturers, and the patent on the hs-CRP test is held by Brigham and
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Women's Health - New Analysis Supports Expanded Use of Statins in Women